查看文章

Monogenic kidney diseases are involved in up to 15% of end-stage kidney diseases in adults, and in 70 % of pediatric patients. When these disorders lead to kidney failure, kidney transplantation is the preferred mode of replacement therapy. Kidney transplantation requires specific considerations depending on the nature of the genetic disorder, the potential oncological risk, the risk of recurrence in the graft, the possibility of specific complications of immunosuppression, and the issue of living donation. The availability of genetic testing should play an increasing role in the evaluation of patients or related living donor candidates before transplantation, relevant for the pre- and post-transplantation management.