作者
Jacklyn N Hellwege, Digna R Velez Edwards, Ayush Giri, Chengxiang Qiu, Jihwan Park, Eric S Torstenson, Jacob M Keaton, OD Wilson, Cassianne Robinson-Cohen, Cecilia P Chung, Christianne L Roumie, Derek Klarin, Scott M Damrauer, Scott L DuVall, Edward Siew, Elvis A Akwo, Matthias Wuttke, Mathias Gorski, Man Li, Yong Li, J Michael Gaziano, Peter WF Wilson, Philip S Tsao, Christopher J O’Donnell, Csaba P Kovesdy, Cristian Pattaro, Anna Köttgen, Katalin Susztak, Todd L Edwards, Adriana M Hung
发表日期
2019/8/26
期刊
Nature communications
卷号
10
期号
1
页码范围
3842
出版商
Nature Publishing Group UK
简介
Chronic kidney disease (CKD), defined by low estimated glomerular filtration rate (eGFR), contributes to global morbidity and mortality. Here we conduct a transethnic Genome-Wide Association Study of eGFR in 280,722 participants of the Million Veteran Program (MVP), with replication in 765,289 participants from the Chronic Kidney Disease Genetics (CKDGen) Consortium. We identify 82 previously unreported variants, confirm 54 loci, and report interesting findings including association of the sickle cell allele of betaglobin among non-Hispanic blacks. Our transcriptome-wide association study of kidney function in healthy kidney tissue identifies 36 previously unreported and nine known genes, and maps gene expression to renal cell types. In a Phenome-Wide Association Study in 192,868 MVP participants using a weighted genetic score we detect associations with CKD stages and complications and kidney …
学术搜索中的文章
JN Hellwege, DR Velez Edwards, A Giri, C Qiu, J Park… - Nature communications, 2019