作者
Eleonora Vianello, Josefine Persson, Björn Andersson, Suzanne van Veen, Thomaz Lüscher Dias, Francesco Santoro, Malin Östensson, Ogonna Obudulu, Christopher Agbajogu, Sara Torkzadeh, Selidji Todagbe Agnandji, Rafi Ahmed, Jenna Anderson, Floriane Auderset, Philip Bejon, Luisa Borgianni, Jessica Brosnahan, Annalisa Ciabattini, Olivier Engler, Marielle C Haks, Ali M Harandi, Donald Gray Heppner, Alice Gerlini, Angela Huttner, Peter G Kremsner, Donata Medaglini, Thomas Monath, Francis Ndungu, Patricia Njuguna, Tom HM Ottenhoff, David Pejoski, Mark Page, Gianni Pozzi, Claire-Anne Siegrist, Sheri Dubey, Micheal J Eichberg, Patrícia Gonzalez-Dias, Paulin Ndong Essone, Lumeka Kabwende, Peter Gottfried Kremsner, Helder Nakaya, Sravya S Nakka, Mariëlle C Haks, Sylvia Rothenberger, Helder I Nakaya
发表日期
2023/12/15
期刊
iScience
卷号
26
期号
12
出版商
Elsevier
简介
The vectored Ebola vaccine rVSVΔG-ZEBOV-GP elicits protection against Ebola Virus Disease (EVD). In a study of forty-eight healthy adult volunteers who received either the rVSVΔG-ZEBOV-GP vaccine or placebo, we profiled intracellular microRNAs (miRNAs) from whole blood cells (WB) and circulating miRNAs from serum-derived extracellular vesicles (EV) at baseline and longitudinally following vaccination. Further, we identified early miRNA signatures associated with ZEBOV-specific IgG antibody responses at baseline and up to one year post-vaccination, and pinpointed target mRNA transcripts and pathways correlated to miRNAs whose expression was altered after vaccination by using systems biology approaches.
Several miRNAs were differentially expressed (DE) and miRNA signatures predicted high or low IgG ZEBOV-specific antibody levels with high classification performance. The top miRNA …
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E Vianello, J Persson, B Andersson, S van Veen… - iScience, 2023