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In order to create a perfect bone scaffold, nanocomposites are the best options, as they can be engineered to have the composition, structure and properties of natural bone. In the present study, the layer-by-layer and hybrid nanofiber scaffold are fabricated by electrospinning method using a combination of PCL/PVP and PVA/β-TCP layers. We study and compare the morphological properties (scanning electron microscope (SEM), swelling ratio and porosity), mechanical properties (tensile strength, elongation at break and tensile modulus) and biodegradability of the scaffolds. The average fiber diameter measured for layer-by-layer and hybrid scaffolds is 446 ± 128 nm and 505 ± 261 nm, respectively. The tensile strength for the layer-by-layer and hybrid scaffolds is 7.40 ± 3.40 MPa and 6.57 ± 1.64 MPa, respectively, and the degradation rate for layer-by-layer and hybrid scaffolds is 26 ± 2% and 40 …