作者
Gerhard-Paul Diller, Rafael Alonso-Gonzalez, Aleksander Kempny, Konstantinos Dimopoulos, Ryo Inuzuka, Georgios Giannakoulas, Lianne Castle, Astrid E Lammers, James Hooper, Anselm Uebing, Lorna Swan, Michael Gatzoulis, Stephen J Wort
发表日期
2012/5/1
期刊
Heart
卷号
98
期号
9
页码范围
736-742
出版商
BMJ Publishing Group Ltd and British Cardiovascular Society
简介
Objective
To assess the relationship between elevated levels of B-type natriuretic peptide (BNP) and outcome in patients with Eisenmenger syndrome.
Design
Retrospective study.
Setting
Tertiary centre for adult congenital heart disease.
Patients
All patients with Eisenmenger syndrome (n=181, age 36.9±12.1 years, 31% with Down syndrome) in whom BNP concentrations were measured as part of routine clinical care were included.
Main outcome measures
The study end point was all cause mortality.
Results
During a median follow-up period of 3.3 years, 20 patients (7 with Down syndrome) died. Higher BNP concentrations were predictive of all cause mortality on univariate analysis in patients with or without Down syndrome. On multivariable Cox proportional hazard analysis, BNP predicted survival independently of renal function, Down syndrome, or 6 min walk test distance (p=0.004). Temporal increases in BNP …
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GP Diller, R Alonso-Gonzalez, A Kempny… - Heart, 2012