作者
Filippos K Triposkiadis, Javed Butler, Georgios Karayannis, Randall C Starling, Gerasimos Filippatos, Kathy Wolski, John Parissis, Charalabos Parisis, Dimitrios Rovithis, Konstantinos Koutrakis, John Skoularigis, Christos-Konstantinos Antoniou, Christina Chrysohoou, Christos Pitsavos, Christodoulos Stefanadis, John Nastas, Themistoklis Tsaknakis, Lilian Mantziari, Georgios Giannakoulas, Haralambos Karvounis, Andreas P Kalogeropoulos, Gregory Giamouzis
发表日期
2014/3/1
期刊
International journal of cardiology
卷号
172
期号
1
页码范围
115-121
出版商
Elsevier
简介
Aims
The role of low-dose dopamine infusion in patients with acute decompensated heart failure (ADHF) remains controversial. We aim to evaluate the efficacy and safety of high- versus low-dose furosemide with or without low-dose dopamine infusion in this patient population.
Methods and results
161 ADHF patients (78 years; 46% female; ejection fraction 31%) were randomized to 8-hour continuous infusions of: a) high-dose furosemide (HDF, n = 50, 20 mg/h), b) low-dose furosemide and low-dose dopamine (LDFD, n = 56, 5 mg/h and 5 μg kg− 1 min− 1 respectively), or c) low-dose furosemide (LDF, n = 55, furosemide 5 mg/h). The main outcomes were 60-day and one-year all-cause mortality (ACM) and hospitalization for HF (HHF). Dyspnea relief (Borg index), worsening renal function (WRF, rise in serum creatinine (sCr) ≥ 0.3 mg/dL), and length of stay (LOS) were also assessed. The urinary output at 2, 4, 6, 8 …
学术搜索中的文章
FK Triposkiadis, J Butler, G Karayannis, RC Starling… - International journal of cardiology, 2014