作者
Jayne Morriss, Anastasia Christakou, Carien M Van Reekum
发表日期
2015/12
期刊
Biology of mood & anxiety disorders
卷号
5
页码范围
1-13
出版商
BioMed Central
简介
Background
Coordination of activity between the amygdala and ventromedial prefrontal cortex (vmPFC) is important for fear-extinction learning. Aberrant recruitment of this circuitry is associated with anxiety disorders. Here, we sought to determine if individual differences in future threat uncertainty sensitivity, a potential risk factor for anxiety disorders, underly compromised recruitment of fear extinction circuitry.
Twenty-two healthy subjects completed a cued fear conditioning task with acquisition and extinction phases. During the task, pupil dilation, skin conductance response, and functional magnetic resonance imaging were acquired. We assessed the temporality of fear extinction learning by splitting the extinction phase into early and late extinction. Threat uncertainty sensitivity was measured using self-reported intolerance of uncertainty (IU).
Results …
学术搜索中的文章
J Morriss, A Christakou, CM Van Reekum - Biology of mood & anxiety disorders, 2015