作者
Bassam Ali Abed Wahab, Nur Ain Salehen, Mahmood Ameen Abdulla, Ahmed Aj Jabbar, Ibrahim Abdel Aziz Ibrahim, Ghassan Almaimani, Mustafa AbdulMonam Zainel, Ghazi A Bamagous, Riyad A Almaimani, Hussain A Almasmoum, Mazen M Ghaith, Wesam F Farrash, Yahya A Almutawif
发表日期
2023/12
期刊
SAGE Open Medicine
卷号
11
页码范围
20503121231216585
出版商
SAGE Publications
简介
Objectives
Pinostrobin (5-hydroxy-7-methoxyflavanone; PN) is a natural active ingredient with numerous biological activities extensively utilized in tumour chemotherapy. The present study investigates the chemo-preventive potentials of PN on azoxymethane-mediated colonic aberrant crypt foci in rats.
Methods
Sprague Dawley rats clustered into five groups, normal control (A) and cancer controls were subcutaneously injected with normal saline and 15 mg/kg azoxymethane, respectively, and nourished on 10% tween 20 and fed on 10% tween 20; reference control (C), injected with 15 mg/kg azoxymethane and injected (intraperitoneal) with 35 mg/kg 5-fluorouracil (5-FU); D and E rat groups received a subcutaneous injection of 15 mg/kg azoxymethane and nourished on 30 and 60 mg/kg of PN, respectively.
Results
The acute toxicity trial showed a lack of any abnormal signs or mortality in rats ingested with 250 …
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B Ali Abed Wahab, N Ain Salehen, MA Abdulla… - SAGE Open Medicine, 2023