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Though biometric systems have been successfully engaged in a number of real-world applications, they are error prone. The challenge is to develop a biometric system that is highly accurate and secure, convenient to use, and easily scalable to a large population. Systems that have the ability to authenticate persons accurately, rapidly, reliably, cost-effectively, friendly to use, and without drastic changes to the existing infrastructures are desired. Despite rapid growth in biometric systems, in the past few decades, a number of core research issues have not yet been fully addressed. Multibiometrics system design is certainly a challenging task since it is very difficult to choose the best possible sources of biometric information and fusion strategy for a particular application. In this chapter, different issues and challenges in designing biometric-based security systems and methodologies involved in overcoming …