作者
Saeed Oraee Yazdani, Mirsepehr Pedram, Maryam Hafizi, Mahboubeh Kabiri, Masoud Soleimani, Mohamad-Mehdi Dehghan, Issa Jahanzad, Yousof Gheisari, Seyed Mahmoud Hashemi
发表日期
2012/8/1
期刊
Tissue and Cell
卷号
44
期号
4
页码范围
205-213
出版商
Churchill Livingstone
简介
Cell therapy has proven to be a highly promising method in clinical applications, raising so much hope for the treatment of injured tissues with low, if any, self regeneration potential such as central and peripheral nervous system. Neurally induced bone marrow derived mesenchymal stem cells (NIMSCs) as well as olfactory ensheathing cells (OECs) were transplanted in a rat model of sub-acute spinal cord injury and the behavioral and histological analyses were conducted. A balloon-compression technique was used to produce an injury at T8–T9 level of spinal cord. After a week post injury, rats were injected with either NIMSCs or OECs at the center of developing lesion cavity, 3mm cranial and 3mm caudal to the cavity. Weekly behavioral assessment using BBB score was done over five-week period post transplantation and finally histological assessment was performed to locate labeled cells in the tissue in order …
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