作者
Chunfeng Qu, Yuting Wang, Pei Wang, Kun Chen, Minjie Wang, Hongmei Zeng, Jianquan Lu, Qianqian Song, Bill H Diplas, Da Tan, Chunsun Fan, Qigao Guo, Zheng Zhu, Huihui Yin, Liping Jiang, Xixi Chen, Hui Zhao, Huan He, Yong Wang, Guangyu Li, Xinyu Bi, Xinming Zhao, Taoyang Chen, Hongping Tang, Chuanguo Lv, Dongmei Wang, Wanqing Chen, Jianguo Zhou, Hong Zhao, Jianqiang Cai, Xiaoyue Wang, Sizhen Wang, Hai Yan, Yi-Xin Zeng, Webster K Cavenee, Yuchen Jiao
发表日期
2019/3/26
期刊
Proceedings of the National Academy of Sciences
卷号
116
期号
13
页码范围
6308-6312
出版商
National Academy of Sciences
简介
Liquid biopsies, based on cell free DNA (cfDNA) and proteins, have shown the potential to detect early stage cancers of diverse tissue types. However, most of these studies were retrospective, using individuals previously diagnosed with cancer as cases and healthy individuals as controls. Here, we developed a liquid biopsy assay, named the hepatocellular carcinoma screen (HCCscreen), to identify HCC from the surface antigen of hepatitis B virus (HBsAg) positive asymptomatic individuals in the community population. The training cohort consisted of individuals who had liver nodules and/or elevated serum α-fetoprotein (AFP) levels, and the assay robustly separated those with HCC from those who were non-HCC with a sensitivity of 85% and a specificity of 93%. We further applied this assay to 331 individuals with normal liver ultrasonography and serum AFP levels. A total of 24 positive cases were identified …
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