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Recent advances in brain imaging technology, coupled with large-scale brain research projects, such as the BRAIN initiative in the U.S. and the European Human Brain Project, allow us to capture brain activity in unprecedented details. In principle, the observed data is expected to substantially shape our knowledge about brain activity, which includes the development of new biomarkers of brain disorders. However, due to the high dimensionality, the analysis of the data is challenging, and selection of relevant features is one of the most important analytic tasks. In many cases, due to the complexity of search space, evolutionary algorithms are appropriate to solve the aforementioned task. In this chapter, we consider the feature selection task from the point of view of classification tasks related to functional magnetic resonance imaging (fMRI) data. Furthermore, we present an empirical comparison of …