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Global wireless communication demands have seen dramatic growth over the past decade along the rapid increase in the numbers of human and machine-based connections. Moreover, next-generation wireless networks and technologies must be developed to support diverse requirements in terms of data rate, latency, reliability for different vertical applications such as e-health, smart factories, and smart cities. To meet these requirements given limited spectrum resource, it becomes critical to leverage under-utilized usable frequency bands and to enhance the spectrum efficiency. To this end, one must address great challenges in engineering hardware components such as antennas and radio frequency circuits to effectively exploit higher frequency bands while improvement of spectrum efficiency requires more sophisticated communications techniques and novel interference and resource management strategies.