作者
Anne-Marie Rick, Matthew B Laurens, Ying Huang, Chenchen Yu, Thomas CS Martin, Carina A Rodriguez, Christina A Rostad, Rebone M Maboa, Lindsey R Baden, Hana M El Sahly, Beatriz Grinsztejn, Glenda E Gray, Cynthia L Gay, Peter B Gilbert, Holly E Janes, James G Kublin, Yunda Huang, Brett Leav, Ian Hirsch, Frank Struyf, Lisa M Dunkle, Kathleen M Neuzil, Lawrence Corey, Paul A Goepfert, Stephen R Walsh, Dean Follmann, Karen L Kotloff, Atoya Adams, Eric Miller, Bruce G Rankin, Steven Shinn, Marshall Nash, Sinikka L Green, Colleen Jacobsen, Jayasree Krishnankutty, Sikhongi Phungwayo, Richard M Glover, Stacy Slechta, Troy Holdeman, Robyn Hartvickson, Amber Grant, Terry L Poling, Terry D Klein, Thomas C Klein, Tracy R Klein, William B Smith, Richard L Gibson, Jennifer Winbigler, Elizabeth Parker, Priyantha N Wijewardane, Eric Bravo, Jeffrey Thessing, Michelle Maxwell, Amanda Horn, Catherine Mary Healy, Christine Akamine, Laurence Chu, R Michelle Chouteau, Michael J Cotugno, George H Bauer, Greg Hachigian, Masaru Oshita, Michael Cancilla, Kristen Kiersey, William Seger, Mohammed Antwi, Allison Green, Anthony Kim, Michael Desjardins, Jennifer A Johnson, Amy Sherman, Judith Borger, Nafisa Saleem, Joel Solis, Martha Carmen Medina, Westly Keating, Edgar Garcia, Cynthia Bueno, Nathan Segall, Douglas S Denham, Thomas Weiss, Ayoade Avworo, Parke Hedges, Cynthia Becher Strout, Rica Santiago, Yvonne Davis, Patty Howenstine, Alison Bondell, Kristin Marks, Tina Wang, Timothy Wilkin, Mary Vogler, Carrie Johnston, Michele P Andrasik, Jessica G Andriesen, Gail Broder, Niles Eaton, Huub G Gelderblom, Rachael McClennen, Nelson Michael, Merlin Robb, Carrie Sopher, Vicki E Miller, Fredric Santiago, Blanca Gomez, Insiya Valika, Amy Starr, Valeria D Cantos, Sheetal Kandiah, Carlos del Rio, Nadine Rouphael, Srilatha Edupuganti, Evan J Anderson, Andres Camacho-Gonzalez, Satoshi Kamidani, Meghan Teherani, David J Diemert, Elissa Malkin, Marc Siegel, Afsoon Roberts, Gary Simon, Bindu Balani, Carolene Stephenson, Steven Sperber, Cristina Cicogna, Marcus J Zervos, Paul Kilgore, Mayur Ramesh, Erica Herc, Kate Zenlea, Abram Burgher, Ann M Milliken, Joseph D Davis, Brendan Levy, Sandra Kelman, Matthew W Doust, Denise Sample, Sandra Erickson, Shane G Christensen, Christopher Matich, James Longe, John Witbeck, James T Peterson, Alexander Clark, Gerald Kelty, Issac Pena-Renteria, Michael J Koren, Darlene Bartilucci, Alpa Patel, Carolyn Tran
发表日期
2023/10/1
期刊
EBioMedicine
卷号
96
出版商
Elsevier
简介
Background
While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection.
Methods
In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous …
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AM Rick, MB Laurens, Y Huang, C Yu, TCS Martin… - EBioMedicine, 2023