作者
Klaus Juergen Schmitz, Jeremias Wohlschlaeger, Hauke Lang, Georgios Charalambos Sotiropoulos, Massimo Malago, Karen Steveling, Henning Reis, Vito Rosario Cicinnati, Kurt Werner Schmid, Hideo Andreas Baba
发表日期
2008/1/1
期刊
Journal of hepatology
卷号
48
期号
1
页码范围
83-90
出版商
Elsevier
简介
BACKGROUND/AIMS
The aim of the study was to determine the prognostic relevance of two kinases in hepatocellular carcinoma (HCC) important in the regulation of cell proliferation and apoptosis: AKT and extracellular regulated kinases (ERK1/2).
METHODS
This study comprised a series of 208 patients incorporating HCCs treated either by surgical resection (n=109) or liver transplantation (n=99). Immunohistochemically demonstrated phospho-ERK1/2 (pERK1/2) and phospho-AKT (pAKT) was correlated with a series of clinico-pathologically relevant parameters (EGFR, Cyclin-D1, HCV/HBV infection, liver cirrhosis, chronic alcohol abuse), proliferative activity, and apoptosis.
RESULTS
Activation of ERK1/2 correlated statistically with the presence of HCV infection. pERK1/2 (P<0.001) and pAKT (P=0.052) expression showed a significant correlation with a decreased overall survival (OS). In multivariate Cox …
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