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We review recent progress on the application of long-range surface plasmon-polariton waveguide biosensors for disease detection. The biosensors are constructed from metal stripe waveguides cladded in Cytop with etched microfluidic channels to expose the stripe surface to the sensing fluid. The waveguides support long-range surface plasmons in integrated optics geometries when excited in an end-fire manner. Application of straight waveguide biosensors to the detection of leukemia, dengue infection, and urinary tract infection in complex fluids such as blood serum, blood plasma, and urine is reviewed.