作者
Anand Reddi, Sarah C Leeper, Anneke C Grobler, Rosemary Geddes, K Holly France, Gillian L Dorse, Willem J Vlok, Mbali Mntambo, Monty Thomas, Kristy Nixon, Helga L Holst, Quarraisha Abdool Karim, Nigel C Rollins, Hoosen M Coovadia, Janet Giddy
发表日期
2007/12
期刊
BMC pediatrics
卷号
7
页码范围
1-13
出版商
BioMed Central
简介
Background
Few studies address the use of paediatric highly active antiretroviral therapy (HAART) in Africa.
Methods
We performed a retrospective cohort study to investigate preliminary outcomes of all children eligible for HAART at Sinikithemba HIV/AIDS clinic in KwaZulu-Natal, South Africa. Immunologic, virologic, clinical, mortality, primary caregiver, and psychosocial variables were collected and analyzed.
Results
From August 31, 2003 until October 31, 2005, 151 children initiated HAART. The median age at HAART initiation was 5.7 years (range 0.3–15.4). Median follow-up time of the cohort after HAART initiation was 8 months (IQR 3.5–13.5). The median change in CD4% from baseline (p < 0.001) was 10.2 (IQR 5.0–13.8) at 6 months (n = 90), and 16.2 (IQR 9.6–20.3) at 12 months (n = 59). Viral loads (VLs) were …
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A Reddi, SC Leeper, AC Grobler, R Geddes… - BMC pediatrics, 2007