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This paper presents the possibilities of validating the microscopic traffic flow simulation model VISSIM, both on a microscopic and a macroscopic level. VISSIM implements a psycho-physical carfollowing model and thus provides a very realistic driving behavior. The complex model offers-but also requires-many model parameters that can be calibrated using measurement data from driving experiments. Some examples of how certain parameters influence driving behavior are given by comparing a simulated approach-and-following-process with records from a probe vehicle. The model parameters can be adjusted to reflect different traffic situations. As examples, the model is validated using measurement data taken from a German freeway and from a US freeway, where driver behavior as well as traffic regulations are substantially different.