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The present study aimed to ascertain the current situation of antimicrobial resistance of Urinary Tract Infections (UTIs) caused by human pathogens. Ten midstream urine samples were collected from adult patients were analyzed for Multidrug Resistant (MDR) strain isolation and identified. The result was clear that E. coli was the predominant pathogen (31.5%) causing UTI, followed by Staphylococcus aureus (20.5%), Klebsiella pneumonia (15.8%), Proteus sp. (7.4%) and Pseudomonas aeruginosa (7.5%). The percentages of resistance of all isolates to the antimicrobial agents were: 83.3% to SXT, 80.6% to Nalidixic acid, 67.3% to Amoxycillin, 61% to Cotrimoxazole, 48.8% to Gentamycin, 46% to ciprofloxacin and 43% to Cephalexin. Isolated UTI strains were tested for susceptibility against antibiotics, few of the antibiotics were sensitive but most of antibiotics showed resistant to the MDR strains. Among this E …