作者
Athanasios Kousathanas, Erola Pairo-Castineira, Konrad Rawlik, Alex Stuckey, Christopher A Odhams, Susan Walker, Clark D Russell, Tomas Malinauskas, Yang Wu, Jonathan Millar, Xia Shen, Katherine S Elliott, Fiona Griffiths, Wilna Oosthuyzen, Kirstie Morrice, Sean Keating, Bo Wang, Daniel Rhodes, Lucija Klaric, Marie Zechner, Nick Parkinson, Afshan Siddiq, Peter Goddard, Sally Donovan, David Maslove, Alistair Nichol, Malcolm G Semple, Tala Zainy, Fiona Maleady-Crowe, Linda Todd, Shahla Salehi, Julian Knight, Greg Elgar, Georgia Chan, Prabhu Arumugam, Christine Patch, Augusto Rendon, David Bentley, Clare Kingsley, Jack A Kosmicki, Julie E Horowitz, Aris Baras, Goncalo R Abecasis, Manuel AR Ferreira, Anne Justice, Tooraj Mirshahi, Matthew Oetjens, Daniel J Rader, Marylyn D Ritchie, Anurag Verma, Tom A Fowler, Manu Shankar-Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Danny McAuley, Hugh Montgomery, Peter JM Openshaw, Paul Elliott, Timothy Walsh, Albert Tenesa, Guy’s and St Thomas’ Hospital team Arbane Gill 62 Bociek Aneta 62 Campos Sara 62 Grau Neus 62 Jones Tim Owen 62 Lim Rosario 62 Marotti Martina 62 Ostermann Marlies 62 Shankar-Hari Manu 62 Whitton Christopher 62, James Cook University Hospital team Bonner Stephen 64 Hugill Keith 64 Jones Jessica 64 Liggett Steven 64 Headlam Evie 64, Royal Stoke University Hospital team Bandla Nageswar 65 Gellamucho Minnie 65 Davies Michelle 65 Thompson Christopher 65, Royal Liverpool University Hospital team Fernandez-Roman Jaime 68 Hamilton David O. 68 Johnson Emily 68 Johnston Brian 68 Martinez Maria Lopez 68 Mulla Suleman 68 Shaw David 68 Waite Alicia AC 68 Waugh Victoria 68 Welters Ingeborg D. 68 Williams Karen 68, Charing Cross Hospital team Antcliffe David 70 Banach Dorota 70 Brett Stephen 70 Coghlan Phoebe 70 Fernandez Ziortza 70 Gordon Anthony 70 Rojo Roceld 70 Arias Sonia Sousa 70 Templeton Maie 70, Nottingham University Hospital team Meredith Megan 71 Morris Lucy 71 Ryan Lucy 71 Clark Amy 71 Sampson Julia 71 Peters Cecilia 71 Dent Martin 71 Langley Margaret 71 Ashraf Saima 71 Wei Shuying 71 Andrew Angela 71, John Radcliffe Hospital team Bashyal Archana 72 Davidson Neil 72 Hutton Paula 72 McKechnie Stuart 72 Wilson Jean 72, Royal Infirmary of Edinburgh team Andrew Gillian 75 Baillie J. Kenneth 75 Barclay Lucy 75 Callaghan Marie 75 Campbell Rachael 75 Clark Sarah 75 Hope Dave 75 Marshall Lucy 75 McCulloch Corrienne 75 Briton Kate 75 Singleton Jo 75 Birch Sophie 75, Queen Alexandra Hospital team Brimfield Lutece 76 Daly Zoe 76 Pogson David 76 Rose Steve 76 Nown Angela 76, Morriston Hospital team Battle Ceri 77 Brinkworth Elaine 77 Harford Rachel 77 Murphy Carl 77 Newey Luke 77 Rees Tabitha 77 Williams Marie 77 Arnold Sophie 77, Addenbrooke’s Hospital team Polgarova Petra 78 Stroud Katerina 78 Summers Charlotte 78 Meaney Eoghan 78 Jones Megan 78 Ng Anthony 78 Agrawal Shruti 78 Pathan Nazima 78 White Deborah 78 Daubney Esther 78 Elston Kay 78, BHRUT (Barking Havering)—Queen’s Hospital and King George Hospital team Grauslyte Lina 79 Hussain Musarat 79 Phull Mandeep 79 Pogreban Tatiana 79 Rosaroso Lace 79 Salciute Erika 79 Franke George 79 Wong Joanna 79 George Aparna 79, Royal Sussex County Hospital team de Gordoa Laura Ortiz-Ruiz 80 Peasgood Emily 80 Phillips Claire 80, Queen Elizabeth Hospital team Bates Michelle 81 Dasgin Jo 81 Gill Jaspret 81 Nilsson Annette 81 Scriven James 81 Collins Amy 82 Khaliq Waqas 82 Gude Estefania Treus 82, Stepping Hill Hospital team Bennett Sara 84 Goodwin Emma 84 Jackson Matthew 84 Kent Alissa 84 Tibke Clare 84 Woodyatt Wiesia 84 Zaki Ahmed 84, Tunbridge Wells Hospital and Maidstone Hospital team Davey Miriam 87 Golden David 87 Seaman Rebecca 87, Royal Gwent Hospital team Cherian Shiney 88 Cutler Sean 88 Heron Anne Emma 88 Roynon-Reed Anna 88 Szakmany Tamas 88 Williams Gemma 88 Richards Owen 88 Cheema Yusuf 88, Royal Berkshire NHS Foundation Trust team Brunton Mark 90 Caterson Jess 90 Coles Holly 90 Frise Matthew 90 Rai Sabi Gurung 90 Jacques Nicola 90 Keating Liza 90 Tilney Emma 90 Bartley Shauna 90 Bhuie Parminder 90, Broomfield Hospital team Gibson Sian 91 Lyle Amanda 91 McNeela Fiona 91 Radhakrishnan Jayachandran 91 Hughes Alistair 91, Northumbria Healthcare NHS Foundation Trust team Yates Bryan 92 Reynolds Jessica 92 Campbell Helen 92 Thompsom Maria 92 Dodds Steve 92 Duffy Stacey 92, Whiston Hospital team Greer Sandra 93 Shuker Karen 93 Tridente Ascanio 93, Croydon University Hospital team Khade Reena 94 Sundar Ashok 94 Tsinaslanidis George 94, York Hospital team Birkinshaw Isobel 95 Carter Joseph 95 Howard Kate 95 Ingham Joanne 95 Joy Rosie 95 Pearson Harriet 95 Roche Samantha 95 Scott Zoe 95, Heartlands Hospital team Bancroft Hollie 96 Bellamy Mary 96 Carmody Margaret 96 Daglish Jacqueline 96 Moore Faye 96 Rhodes Joanne 96 Sangombe Mirriam 96 Kadiri Salma 96 Scriven James 96, Ashford and St Peter’s Hospital team Croft Maria 97 White Ian 97 Frost Victoria 97 Aquino Maia 97, Barnet Hospital team Jha Rajeev 98 Krishnamurthy Vinodh 98 Lim Lai 98 Lim Li 98, East Surrey Hospital team Combes Edward 99 Joefield Teishel 99 Monnery Sonja 99 Beech Valerie 99 Trotman Sallyanne 99, Ninewells Hospital team Almaden-Boyle Christine 100 Austin Pauline 100 Cabrelli Louise 100 Cole Stephen 100 Casey Matt 100 Chapman Susan 100 Whyte Clare 100, Southampton General Hospital team Criste Kristine 103 Cusack Rebecca 103 Golder Kim 103 Golding Hannah 103 Jones Oliver 103 Leggett Samantha 103 Male Michelle 103 Marani Martyna 103 Prager Kirsty 103 Williams Toran 103 Roberts Belinda 103 Salmon Karen 103, Blackpool Victoria Hospital team Benham Leonie 106 Bradshaw Zena 106 Brown Joanna 106 Caswell Melanie 106 Cupitt Jason 106 Melling Sarah 106 Preston Stephen 106 Slawson Nicola 106 Stoddard Emma 106 Warden Scott 106, Royal Glamorgan Hospital team Deacon Bethan 107 Lynch Ceri 107 Pothecary Carla 107 Roche Lisa 107 Howe Gwenllian Sera 107 Singh Jayaprakash 107 Turner Keri 107 Ellis Hannah 107 Stroud Natalie 107, Royal Oldham Hospital team Hunt Jodie 108 Dearden Joy 108 Dobson Emma 108 Drummond Andy 108 Mulcahy Michelle 108 Munt Sheila 108 O’Connor Grainne 108 Philbin Jennifer 108 Rishton Chloe 108 Tully Redmond 108 Winnard Sarah 108, Glasgow Royal Infirmary team Cathcart Susanne 109 Duffy Katharine 109 Puxty Alex 109 Puxty Kathryn 109 Turner Lynne 109 Ireland Jane 109 Semple Gary 109, St James’s University Hospital and Leeds General Infirmary team Long Kate 110 Whiteley Simon 110 Wilby Elizabeth 110 Ogg Bethan 110, University Hospital North Durham team Cowton Amanda 111 112 Kay Andrea 111 112 Kent Melanie 111 112 Potts Kathryn 111 112 Wilkinson Ami 111 112 Campbell Suzanne 111 112 Brown Ellen 111 112, Fairfield General Hospital team Melville Julie 113 Naisbitt Jay 113 Joseph Rosane 113 Lazo Maria 113 Walton Olivia 113 Neal Alan 113, Wythenshawe Hospital team Alexander Peter 114 Allen Schvearn 114 Bradley-Potts Joanne 114 Brantwood Craig 114 Egan Jasmine 114 Felton Timothy 114 Padden Grace 114 Ward Luke 114 Moss Stuart 114 Glasgow Susannah 114, Royal Alexandra Hospital team Abel Lynn 115 Brett Michael 115 Digby Brian 115 Gemmell Lisa 115 Hornsby James 115 MacGoey Patrick 115 O’Neil Pauline 115 Price Richard 115 Rodden Natalie 115 Rooney Kevin 115 Sundaram Radha 115 Thomson Nicola 115, Good Hope Hospital team Hopkins Bridget 116 Scriven James 116 Thrasyvoulou Laura 116 Willis Heather 116, Tameside General Hospital team Clark Martyn 117 Coulding Martina 117 Jude Edward 117 McCormick Jacqueline 117 Mercer Oliver 117 Potla Darsh 117 Rehman Hafiz 117 Savill Heather 117 Turner Victoria 117, Royal Derby Hospital team Downes Charlotte 118 Holding Kathleen 118 Riches Katie 118 Hilton Mary 118 Hayman Mel 118 Subramanian Deepak 118 Daniel Priya 118, Medway Maritime Hospital team Adanini Oluronke 119 Bhatia Nikhil 119 Msiska Maines 119 Collins Rebecca 119, Poole Hospital team Camsooksai Julie 121 Humphrey Charlotte 121 Jenkins Sarah 121 Reschreiter Henrik 121 Wadams Beverley 121 Death Yasmin 121, Queens Hospital Burton team Bell Gillian 123 English Katy 123 Katary Amro 123 Wilcox Louise 123, Aberdeen Royal Infirmary team Allan Angela 125 Anderson Felicity 125 Kaye Callum 125 Liew Jade 125 Medhora Jasmine 125 Scott Teresa 125 Trumper Erin 125 Botello Adriana 125, Derriford Hospital team Lankester Liana 126 Nikitas Nikitas 126 Wells Colin 126 Stowe Bethan 126 Spencer Kayleigh 126, Manchester Royal Infirmary team Brandwood Craig 127 Smith Lara 127 Clark Richard 127 Birchall Katie 127 Kolakaluri Laurel 127 Baines Deborah 127 Sukumaran Anila 127, William Harvey Hospital team Cosier Tracey 129 Millen Gemma 129 Richardson Neil 129 Schumacher Natasha 129 Weston Heather 129 Rand James 129, Queen Elizabeth University Hospital team Baxter Nicola 130 Henderson Steven 130 Kennedy-Hay Sophie 130 McParland Christopher 130 Rooney Laura 130 Sim Malcolm 130 McCreath Gordan 130, Bristol Royal Infirmary team Bewley Jeremy 132 Garland Zoe 132 Grimmer Lisa 132 Gumbrill Bethany 132 Johnson Rebekah 132 Sweet Katie 132 Webster Denise 132 Efford Georgia 132, Norfolk and Norwich University Hospital (NNUH) team Convery Karen 133 Fottrell-Gould Deirdre 133 Hudig Lisa 133 Keshet-Price Jocelyn 133 Randell Georgina 133 Stammers Katie 133, Queen Elizabeth Hospital Gateshead team Bokhari Maria 134 Linnett Vanessa 134 Lucas Rachael 134 McCormick Wendy 134 Ritzema Jenny 134 Sanderson Amanda 134 Wild Helen 134, Sunderland Royal Hospital team Rostron Anthony 135 Roy Alistair 135 Woods Lindsey 135 Cornell Sarah 135 Wakinshaw Fiona 135 Rogerson Kimberley 135 Jarmain Jordan 135, Aintree University Hospital team Parker Robert 136 Reddy Amie 136 Turner-Bone Ian 136 Wilding Laura 136 Harding Peter 136, Hull Royal Infirmary team Abernathy Caroline 137 Foster Louise 137 Gratrix Andrew 137 Martinson Vicky 137 Parkinson Priyai 137 Stones Elizabeth 137 Carbral-Ortega Llucia 138, University College Hospital team Bercades Georgia 139 Brealey David 139 Hass Ingrid 139 MacCallum Niall 139 Martir Gladys 139 Raith Eamon 139 Reyes Anna 139 Smyth Deborah 139, Royal Devon and Exeter Hospital team Zitter Letizia 140 Benyon Sarah 140 Marriott Suzie 140 Park Linda 140 Keenan Samantha 140 Gordon Elizabeth 140 Quinn Helen 140 Baines Kizzy 140, Royal Papworth Hospital team Cagova Lenka 141 Fofano Adama 141 Garner Lucie 141 Holcombe Helen 141 Mepham Sue 141 Mitchell Alice Michael 141 Mwaura Lucy 141 Praman Krithivasan 141 Vuylsteke Alain 141 Zamikula Julie 141, Ipswich Hospital team Purewal Bally 142 Rivers Vanessa 142 Bell Stephanie 142, Southmead Hospital team Blakemore Hayley 143 Borislavova Borislava 143 Faulkner Beverley 143 Gendall Emma 143 Goff Elizabeth 143 Hayes Kati 143 Thomas Matt 143 Worner Ruth 143 Smith Kerry 143 Stephens Deanna 143, Milton Keynes University Hospital team Mew Louise 144 Mwaura Esther 144 Stewart Richard 144 Williams Felicity 144 Wren Lynn 144 Sutherland Sara-Beth 144, Royal Hampshire County Hospital team Bevan Emily 145 Martin Jane 145 Trodd Dawn 145 Watson Geoff 145 Wrey Brown Caroline 145, Stoke Mandeville Hospital team Burn Iona 147 Hambrook Geraldine 147 Manso Katarina 147 Penn Ruth 147 Shanmugasundaram Pradeep 147 Tebbutt Julie 147 Thornton Danielle 147, University Hospital of Wales team Cole Jade 148 Davies Michelle 148 Davies Rhys 148 Duffin Donna 148 Hill Helen 148 Player Ben 148 Thomas Emma 148 Williams Angharad 148, Basingstoke and North Hampshire Hospital team Griffin Denise 149 Muchenje Nycola 149 Mupudzi Mcdonald 149 Partridge Richard 149 Conyngham Jo-Anna 149 Thomas Rachel 149 Wright Mary 149 Corral Maria Alvarez 149, Arrowe Park Hospital team Jacob Reni 150 Jones Cathy 150 Denmade Craig 150, Chesterfield Royal Hospital Foundation Trust team Beavis Sarah 151 Dale Katie 151 Gascoyne Rachel 151 Hawes Joanne 151 Pritchard Kelly 151 Stevenson Lesley 151 Whileman Amanda 151, Musgrove Park Hospital team Doble Patricia 152 Hutter Joanne 152 Pawley Corinne 152 Shovelton Charmaine 152 Vaida Marius 152, Peterborough City Hospital team Butcher Deborah 153 154 O’Sullivan Susie 153 154 Butterworth-Cowin Nicola 153 154
发表日期
2022/7/7
期刊
Nature
卷号
607
期号
7917
页码范围
97-103
出版商
Nature Publishing Group UK
简介
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization, – after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of …
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