作者
Betty Y Yang, Natalie Bulger, Richard Chocron, Catherine R Counts, Chris Drucker, Lihua Yin, Megin Parayil, Nicholas J Johnson, Nona Sotoodehenia, Peter J Kudenchuk, Michael R Sayre, Thomas D Rea
发表日期
2022/8/1
期刊
JAMA Network Open
卷号
5
期号
8
页码范围
e2226191-e2226191
出版商
American Medical Association
简介
Importance
Epinephrine improves return of spontaneous circulation after out-of-hospital cardiac arrest (OHCA). These beneficial cardiac effects do not directly translate to better neurologic outcomes, possibly because of epinephrine-induced microvascular effects that produce critical brain ischemia.
Objective
To examine whether targeted temperature management (TTM) modifies the adverse association between increasing prehospital epinephrine dose and neurologically favorable survival.
Design, Setting, and Participants
This retrospective cohort study assessed 14 612 adults from Seattle and King County, Washington, with nontraumatic OHCA between January 1, 2008, and December 31, 2018, and included those who achieved return of spontaneous circulation and were unconscious at hospital admission. Data analysis was performed from April 2021 to May 2022.
Exposures
Epinephrine dose and TTM during …
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BY Yang, N Bulger, R Chocron, CR Counts, C Drucker… - JAMA Network Open, 2022