作者
Emmanuelle Genin, Didier Hannequin, David Wallon, Kristel Sleegers, Mikko Hiltunen, Onofre Combarros, Marıa Jesús Bullido, Sebastiaan Engelborghs, Peter De Deyn, Claudine Berr, Florence Pasquier, Bruno Dubois, Gloria Tognoni, Nathalie Fiévet, Nathalie Brouwers, Karolien Bettens, Beatrice Arosio, Eliecer Coto, Maria Del Zompo, Ignacio Mateo, Jacques Epelbaum, Ana Frank-Garcia, Seppo Helisalmi, Elisa Porcellini, Alberto Pilotto, Paola Forti, Raffaele Ferri, Elio Scarpini, Gabriele Siciliano, Vincenzo Solfrizzi, Sandro Sorbi, Gianfranco Spalletta, Fernando Valdivieso, Saila Vepsäläinen, Victoria Alvarez, Paolo Bosco, Michelangelo Mancuso, Francesco Panza, Benedetta Nacmias, Paola Bossù, Olivier Hanon, Paola Piccardi, Giorgio Annoni, Davide Seripa, Daniela Galimberti, Federico Licastro, Hilkka Soininen, Jean-François Dartigues, M Ilyas Kamboh, Christine Van Broeckhoven, Jean Charles Lambert, Philippe Amouyel, Dominique Campion
发表日期
2011/9
期刊
Molecular psychiatry
卷号
16
期号
9
页码范围
903-907
出版商
Nature Publishing Group
简介
Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are currently not accurately known and odds ratios alone are insufficient to assess these risks. We calculated AD LTR in 7351 cases and 10 132 controls from Caucasian ancestry using Rochester (USA) incidence data. At the age of 85 the LTR of AD without reference to APOE genotype was 11% in males and 14% in females. At the same age, this risk ranged from 51% for APOE44 male carriers to 60% for APOE44 female carriers, and from 23% for APOE34 male carriers to 30% for APOE34 female carriers, consistent with semi-dominant inheritance of a moderately penetrant gene. Using PAQUID (France) incidence data, estimates were globally similar except that at age 85 the LTRs reached 68 and 35% for APOE 44 and APOE 34 female carriers, respectively. These risks are more similar to those of major genes in Mendelian …
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E Genin, D Hannequin, D Wallon, K Sleegers… - Molecular psychiatry, 2011