作者
Weiya Zhang, Michael Doherty, G Peat, MA Bierma-Zeinstra, NK Arden, B Bresnihan, G Herrero-Beaumont, S Kirschner, BF Leeb, LS Lohmander, B Mazières, Karel Pavelka, Leonardo Punzi, AK So, T Tuncer, I Watt, JW Bijlsma
发表日期
2010/3/1
来源
Annals of the rheumatic diseases
卷号
69
期号
3
页码范围
483-489
出版商
BMJ Publishing Group Ltd
简介
Objective
To develop evidence-based recommendations for the diagnosis of knee osteoarthritis (OA).
Methods
The multidisciplinary guideline development group, representing 12 European countries, generated 10 key propositions regarding diagnosis using a Delphi consensus approach. For each recommendation, research evidence was searched systematically. Whenever possible, the sensitivity, specificity and likelihood ratio were calculated for individual diagnostic indicators and a diagnostic ladder was developed using Bayes' method. Secondary analyses were undertaken to test directly the recommendations using multiple predictive models in two populations from the UK and the Netherlands. Strength of recommendation was assessed by the EULAR visual analogue scale.
Results
Recommendations covered the definition of knee OA and its risk factors, subsets, typical symptoms and signs, the use of …
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