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The pursuit of optimal health and longevity is a long-standing human aspiration [1, 2]. Advances in public health policies and population medicine have significantly extended life expectancy, which has tripled from 20–30 years a century and a half ago. However, this has also led to an increase in agerelated diseases. As we age, stem cells, the foundation of every organ and tissue in our body, lose their regenerative capacity, leading to tissue decline and age-related diseases. Environmental conditions and disease treatments can also negatively impact the quality of life and health span [3]. With an aging society (eg, China’s population of people aged over 60 years is predicted to reach 28% by 2040), there is a growing need for interventions to manage aging as a risk factor for chronic diseases. Recent developments in the biomarkers of aging can help identify and evaluate health span and longevity interventions [4 …