作者
Max Lam, Nur Amirah Abdul Rashid, Sara-Ann Lee, Jeanette Lim, George Foussias, Gagan Fervaha, Stephan Ruhrman, Gary Remington, Jimmy Lee
发表日期
2015/12/1
期刊
European Neuropsychopharmacology
卷号
25
期号
12
页码范围
2187-2196
出版商
Elsevier
简介
Social amotivation and diminished expression have been reported to underlie negative symptomatology in schizophrenia. In the current study we sought to establish and validate these negative symptom domains in a large cohort of schizophrenia subjects (n=887) and individuals who are deemed to be Ultra-High Risk (UHR) for psychosis. Confirmatory factor analysis conducted on PANSS item domains demonstrate that the dual negative symptom domains exist in schizophrenia and UHR subjects. We further sought to examine if these negative symptom domains were associated with functioning in UHR subjects. Linear regression analyses confirmed that social amotivation predicted functioning in UHR subjects prospectively at 1 year follow up. Results suggest that the association between social amotivation and functioning is generalisable beyond schizophrenia populations to those who are at-risk of developing …
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