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An overview of the use of artificial intelligence (AI) in general hospital medicine is given in this chapter, with a particular emphasis on high-value treatment, perioperative management, patient safety and quality issues, screening, vaccine recommendations, and telemedicine. AI has the potential to deliver standardized care more accurately and effectively. AI helps with risk assessment and therapy optimization in perioperative care. However, there are still issues with data accessibility and disease-specific checks. AI can help with patient safety and quality issues, but medication and diagnostic errors must be addressed. AI screening has also demonstrated promise for several internal medicine diseases, including cancer, diabetes, diabetes-related conditions, cardiovascular disease, and mental health issues. AI can also help with telehealth and vaccine development, facilitating remote diagnosis and enhancing patient …