作者
Tomas Kalincik, Vino Vivek, Vilija Jokubaitis, Jeannette Lechner-Scott, Maria Trojano, Guillermo Izquierdo, Alessandra Lugaresi, Francois Grand’Maison, Raymond Hupperts, Celia Oreja-Guevara, Roberto Bergamaschi, Gerardo Iuliano, Raed Alroughani, Vincent Van Pesch, Maria Pia Amato, Mark Slee, Freek Verheul, Ricardo Fernandez-Bolanos, Marcela Fiol, Daniele La Spitaleri, Edgardo Cristiano, Orla Gray, Jose Antonio Cabrera-Gomez, Vahid Shaygannejad, Joseph Herbert, Steve Vucic, Merilee Needham, Tatjana Petkovska-Boskova, Carmen-Adella Sirbu, Pierre Duquette, Marc Girard, Pierre Grammond, Cavit Boz, Giorgio Giuliani, Maria Edite Rio, Michael Barnett, Shlomo Flechter, Fraser Moore, Bhim Singhal, Elizabeth Alejandra Bacile, Maria Laura Saladino, Cameron Shaw, Eli Skromne, Dieter Poehlau, Norbert Vella, Timothy Spelman, Danny Liew, Trevor J Kilpatrick, Helmut Butzkueven
发表日期
2013/12/1
期刊
Brain
卷号
136
期号
12
页码范围
3609-3617
出版商
Oxford University Press
简介
The aim of this work was to evaluate sex differences in the incidence of multiple sclerosis relapses; assess the relationship between sex and primary progressive disease course; and compare effects of age and disease duration on relapse incidence. Annualized relapse rates were calculated using the MSBase registry. Patients with incomplete data or <1 year of follow-up were excluded. Patients with primary progressive multiple sclerosis were only included in the sex ratio analysis. Relapse incidences over 40 years of multiple sclerosis or 70 years of age were compared between females and males with Andersen-Gill and Tweedie models. Female-to-male ratios stratified by annual relapse count were evaluated across disease duration and patient age and compared between relapse-onset and primary progressive multiple sclerosis. The study cohort consisted of 11 570 eligible patients with relapse-onset and …
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T Kalincik, V Vivek, V Jokubaitis, J Lechner-Scott… - Brain, 2013