作者
Benjamin P Trewin, Russell C Dale, Jessica Qiu, Melissa Chu, Niroshan Jeyakumar, Fionna Dela Cruz, Jane Andersen, Pakeeran Siriratnam, Kit Kwan M Ma, Todd A Hardy, Anneke van der Walt, Jeanette Lechner-Scott, Helmut Butzkueven, Simon A Broadley, Michael H Barnett, Stephen W Reddel, Fabienne Brilot, Tomas Kalincik, Sudarshini Ramanathan
发表日期
2024/5/13
期刊
Journal of Neurology, Neurosurgery & Psychiatry
出版商
BMJ Publishing Group Ltd
简介
Background
We sought to identify an optimal oral corticosteroid regimen at the onset of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), which would delay time to first relapse while minimising cumulative corticosteroid exposure.
Methods
In a retrospective multicentre cohort study, Cox proportional hazards models examined the relationship between corticosteroid course as a time-varying covariate and time to first relapse. Simon-Makuch and Kaplan-Meier plots identified an optimal dosing strategy.
Results
We evaluated 109 patients (62 female, 57%; 41 paediatric, 38%; median age at onset 26 years, (IQR 8–38); median follow-up 6.2 years (IQR 2.6–9.6)). 76/109 (70%) experienced a relapse (median time to first relapse 13.7 months; 95% CI 8.2 to 37.9). In a multivariable model, higher doses of oral prednisone delayed time to first relapse with an effect estimate of 3.7% (95% CI 0.8% to 6 …
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BP Trewin, RC Dale, J Qiu, M Chu, N Jeyakumar… - Journal of Neurology, Neurosurgery & Psychiatry, 2024