作者
Vilija G Jokubaitis, Tim Spelman, Tomas Kalincik, Johannes Lorscheider, Eva Havrdova, Dana Horakova, Pierre Duquette, Marc Girard, Alexandre Prat, Guillermo Izquierdo, Pierre Grammond, Vincent Van Pesch, Eugenio Pucci, François Grand'Maison, Raymond Hupperts, Franco Granella, Patrizia Sola, Roberto Bergamaschi, Gerardo Iuliano, Daniele Spitaleri, Cavit Boz, Suzanne Hodgkinson, Javier Olascoaga, Freek Verheul, Pamela McCombe, Thor Petersen, Csilla Rozsa, Jeannette Lechner‐Scott, Maria Laura Saladino, Deborah Farina, Pietro Iaffaldano, Damiano Paolicelli, Helmut Butzkueven, Alessandra Lugaresi, Maria Trojano, MSBase Study Group
发表日期
2016/7
期刊
Annals of neurology
卷号
80
期号
1
页码范围
89-100
简介
Objective
To identify predictors of 10‐year Expanded Disability Status Scale (EDSS) change after treatment initiation in patients with relapse‐onset multiple sclerosis.
Methods
Using data obtained from MSBase, we defined baseline as the date of first injectable therapy initiation. Patients need only have remained on injectable therapy for 1 day and were monitored on any approved disease‐modifying therapy, or no therapy thereafter. Median EDSS score changes over a 10‐year period were determined. Predictors of EDSS change were then assessed using median quantile regression analysis. Sensitivity analyses were further performed.
Results
We identified 2,466 patients followed up for at least 10 years reporting post‐baseline disability scores. Patients were treated an average 83% of their follow‐up time. EDSS scores increased by a median 1 point (interquartile range = 0–2) at 10 years post‐baseline …
学术搜索中的文章
VG Jokubaitis, T Spelman, T Kalincik, J Lorscheider… - Annals of neurology, 2016