作者
Lu Ping Tan, Geok Wee Tan, Vijaya Mohan Sivanesan, Siang Ling Goh, Xun Jin Ng, Chun Shen Lim, Wee Ric Kim, Taznim Begam Binti Mohd Mohidin, Nor Soleha Mohd Dali, Siew Hoon Ong, Chun Ying Wong, Halimuddin Sawali, Yoke Yeow Yap, Faridah Hassan, Kin Choo Pua, Cheng Eng Koay, Ching Ching Ng, Alan Soo‐Beng Khoo, Malaysian Nasopharyngeal Carcinoma Study Group
发表日期
2020/4/15
期刊
International journal of cancer
卷号
146
期号
8
页码范围
2336-2347
出版商
John Wiley & Sons, Inc.
简介
Nasopharyngeal carcinoma (NPC) is originated from the epithelial cells of nasopharynx, Epstein–Barr virus (EBV)‐associated and has the highest incidence and mortality rates in Southeast Asia. Late presentation is a common issue and early detection could be the key to reduce the disease burden. Sensitivity of plasma EBV DNA, an established NPC biomarker, for Stage I NPC is controversial. Most newly reported NPC biomarkers have neither been externally validated nor compared to the established ones. This causes difficulty in planning for cost‐effective early detection strategies. Our study systematically evaluated six established and four new biomarkers in NPC cases, population controls and hospital controls. We showed that BamHI‐W 76 bp remains the most sensitive plasma biomarker, with 96.7% (29/30), 96.7% (58/60) and 97.4% (226/232) sensitivity to detect Stage I, early stage and all NPC …
学术搜索中的文章
LP Tan, GW Tan, VM Sivanesan, SL Goh, XJ Ng… - International journal of cancer, 2020