作者
Jingyou Yu, Lisa H Tostanoski, Lauren Peter, Noe B Mercado, Katherine McMahan, Shant H Mahrokhian, Joseph P Nkolola, Jinyan Liu, Zhenfeng Li, Abishek Chandrashekar, David R Martinez, Carolin Loos, Caroline Atyeo, Stephanie Fischinger, John S Burke, Matthew D Slein, Yuezhou Chen, Adam Zuiani, Felipe JN Lelis, Meghan Travers, Shaghayegh Habibi, Laurent Pessaint, Alex Van Ry, Kelvin Blade, Renita Brown, Anthony Cook, Brad Finneyfrock, Alan Dodson, Elyse Teow, Jason Velasco, Roland Zahn, Frank Wegmann, Esther A Bondzie, Gabriel Dagotto, Makda S Gebre, Xuan He, Catherine Jacob-Dolan, Marinela Kirilova, Nicole Kordana, Zijin Lin, Lori F Maxfield, Felix Nampanya, Ramya Nityanandam, John D Ventura, Huahua Wan, Yongfei Cai, Bing Chen, Aaron G Schmidt, Duane R Wesemann, Ralph S Baric, Galit Alter, Hanne Andersen, Mark G Lewis, Dan H Barouch
发表日期
2020/8/14
期刊
Science
卷号
369
期号
6505
页码范围
806-811
出版商
American Association for the Advancement of Science
简介
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made the development of a vaccine a top biomedical priority. In this study, we developed a series of DNA vaccine candidates expressing different forms of the SARS-CoV-2 spike (S) protein and evaluated them in 35 rhesus macaques. Vaccinated animals developed humoral and cellular immune responses, including neutralizing antibody titers at levels comparable to those found in convalescent humans and macaques infected with SARS-CoV-2. After vaccination, all animals were challenged with SARS-CoV-2, and the vaccine encoding the full-length S protein resulted in >3.1 and >3.7 log10 reductions in median viral loads in bronchoalveolar lavage and nasal mucosa, respectively, as compared with viral loads in sham controls. Vaccine-elicited neutralizing antibody titers …
学术搜索中的文章
J Yu, LH Tostanoski, L Peter, NB Mercado, K McMahan… - Science, 2020