作者
Georgia V Kapoula, Panagiota I Kontou, Pantelis G Bagos
发表日期
2019/7/1
来源
The Journal of Applied Laboratory Medicine
卷号
4
期号
1
页码范围
78-94
出版商
Oxford University Press
简介
Background
Currently, there is a lack of prediction markers for diabetic nephropathy (DN) in patients with type 1 and type 2 diabetes mellitus (T1DM/T2DM). The aim of this systematic review and meta-analysis was to evaluate the value of a promising biomarker, neutrophil gelatinase-associated lipocalin (NGAL), in both serum and urine for the diagnosis of early DN in T1DM and T2DM patients with different stages of albuminuria.
Methods
A comprehensive search was performed on PubMed by 2 reviewers until September 2018. Studies in which (a) the degree of DN was determined according to the urinary albumin/creatinine ratio and (b) NGAL was measured in healthy individuals and in diabetes patients with DN were included in the meta-analysis. For each study, a 2 × 2 contingency table was formulated. Sensitivity, specificity, and other estimates of accuracy were calculated …
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GV Kapoula, PI Kontou, PG Bagos - The Journal of Applied Laboratory Medicine, 2019