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Leonard Ho PhD a,*, Katherine Lloyd MBChB b, Martin Taylor-Rowan PhD c, Shoba Dawson PhD b, Monica Logan MBChB c, Stephanie Leitch MBChB c, Terence J. Quinn MD c, Susan D. Shenkin MD a, d, Steve W. Parry PhD e, Heather Jarman DHC f, Emily J. Henderson PhD b, g a Advanced Care Research Centre, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom b Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom c School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom d Ageing and Health Research Group, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom e Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom f Emergency Department Clinical Research Group, St George’s University Hospitals NHS Foundation Trust, London, United Kingdom g Royal United Hospitals Bath NHS Foundation Trust, Bath, United Kingdom