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Big data powered Deep Learning (DL) and its applications have blossomed in recent years, fueled by three technological trends: a large amount of digitized data openly accessible, a growing number of DL software frameworks in open source and commercial markets, and a selection of affordable parallel computing hardware devices. However, no single DL framework, to date, dominates in terms of performance and accuracy even for baseline classification tasks on standard datasets, making the selection of a DL framework an overwhelming task. This paper takes a holistic approach to conduct empirical comparison and analysis of four representative DL frameworks with three unique contributions. First , given a selection of CPU-GPU configurations, we show that for a specific DL framework, different configurations of its hyper-parameters may have a significant impact on both performance and accuracy of DL …