作者
Louise Fleming, Clare Murray, Aruna T Bansal, Simone Hashimoto, Hans Bisgaard, Andrew Bush, Urs Frey, Gunilla Hedlin, Florian Singer, Wim M van Aalderen, Nadja H Vissing, Zaraquiza Zolkipli, Anna Selby, Stephen Fowler, Dominick Shaw, Kian Fan Chung, Ana R Sousa, Scott Wagers, Julie Corfield, Ioannis Pandis, Anthony Rowe, Elena Formaggio, Peter J Sterk, Graham Roberts
发表日期
2015/11/1
期刊
European Respiratory Journal
卷号
46
期号
5
页码范围
1322-1333
出版商
European Respiratory Society
简介
U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches.
A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 school-age children with mild/moderate asthma and 53 preschoolers with mild/moderate wheeze in a cross-sectional study.
Despite high-dose treatment, the severe cohorts had more severe exacerbations compared with the mild/moderate ones (annual medians: school-aged 3.0 versus 1.1, preschool 3.9 versus 1.8; p<0.001). Exhaled tobacco exposure was common in the severe wheeze cohort. Almost all participants in each cohort were atopic and had a normal body mass index. Asthma-related quality of life, as assessed by the Paediatric Asthma Quality of Life Questionnaire (PAQLQ) and the Paediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ …
学术搜索中的文章
L Fleming, C Murray, AT Bansal, S Hashimoto… - European Respiratory Journal, 2015