作者
Azra Frkatović-Hodžić, Anika Mijakovac, Karlo Miškec, Arina Nostaeva, Sodbo Z Sharapov, Arianna Landini, Toomas Haller, Erik van den Akker, Sapna Sharma, Rafael RC Cuadrat, Massimo Mangino, Yong Li, Toma Keser, Najda Rudman, Tamara Štambuk, Maja Pučić-Baković, Irena Trbojević-Akmačić, Ivan Gudelj, Jerko Štambuk, Tea Pribić, Barbara Radovani, Petra Tominac, Krista Fischer, Marian Beekman, Manfred Wuhrer, Christian Gieger, Matthias B Schulze, Clemens Wittenbecher, Ozren Polasek, Caroline Hayward, James F Wilson, Tim D Spector, Anna Köttgen, Frano Vučković, Yurii S Aulchenko, Aleksandar Vojta, Jasminka Krištić, Lucija Klarić, Vlatka Zoldoš, Gordan Lauc
发表日期
2023/12/12
期刊
Aging (Albany NY)
卷号
15
期号
24
页码范围
14509
出版商
Impact Journals, LLC
简介
Glycans are an essential structural component of immunoglobulin G (IgG) that modulate its structure and function. However, regulatory mechanisms behind this complex posttranslational modification are not well known. Previous genome-wide association studies (GWAS) identified 29 genomic regions involved in regulation of IgG glycosylation, but only a few were functionally validated. One of the key functional features of IgG glycosylation is the addition of galactose (galactosylation), a trait which was shown to be associated with ageing. We performed GWAS of IgG galactosylation (N= 13,705) and identified 16 significantly associated loci, indicating that IgG galactosylation is regulated by a complex network of genes that extends beyond the galactosyltransferase enzyme that adds galactose to IgG glycans. Gene prioritization identified 37 candidate genes. Using a recently developed CRISPR/dCas9 system we …
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A Frkatović-Hodžić, A Mijakovac, K Miškec, A Nostaeva… - Aging (Albany NY), 2023