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Introduction: Alterations in the glycosylation pattern of immunoglobulin G (IgG) play a key role in the transition from healthy to diseased tissue, and have been related to inflammation, immune function, and cardiovascular disease (CVD) risk factors.

Hypothesis: We hypothesized that IgG glycosylation patterns are associated with the risk of developing CVD events.

Methods: IgG glycosylation profiles were measured using ultra-performance liquid chromatography on baseline plasma samples from two nested CVD case-control studies within the JUPITER (NCT00239681; Npairs=162; discovery) and the TNT (Npairs=367, validation) randomized trials. In both cohorts, we used conditional logistic regression adjusted for age, sex, statin, race, LDLC, smoking, hypertension, BMI, HDLC, triglycerides, and hs-CRP to examine the association of 24 IgG glycan peaks (IgG-GPs) with incident CVD events. In the controls sample …