作者
Giorgia Michelini, Joseph Jurgiel, Ioannis Bakolis, Celeste HM Cheung, Philip Asherson, Sandra K Loo, Jonna Kuntsi, Iman Mohammad-Rezazadeh
发表日期
2019
期刊
Translational Psychiatry
卷号
9
期号
136
出版商
Springer Nature
简介
We previously provided initial evidence for cognitive and event-related potential markers of persistence/remission of attention-deficit/hyperactivity disorder (ADHD) from childhood to adolescence and adulthood. Here, using a novel brain-network connectivity approach, we aimed to examine whether task-based functional connectivity reflects a marker of ADHD remission or an enduring deficit unrelated to ADHD outcome. High-density EEG was recorded in a follow-up of 110 adolescents and young adults with childhood ADHD (87 persisters, 23 remitters) and 169 typically developing individuals during an arrow-flanker task, eliciting cognitive control. Functional connectivity was quantified with network-based graph-theory metrics before incongruent (high-conflict) target onset (pre-stimulus), during target processing (post-stimulus) and in the degree of change between pre-stimulus/post-stimulus. ADHD outcome was …
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