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We previously reported that the ApoE e4e4 genotype was associated with COVID-19 test positivity (odds ratio [OR]= 2.31, 95% CI: 1.65–3.24, p= 1.19× 10− 6)(1) in the UK Biobank (UKB) cohort, during the epidemic peak in England, from March 16 to April 26, 2020 (2). With more COVID-19 test results (March 16 to May 31, 2020) and mortality data (to March 31, 2020, with incomplete data for April 2020) linked to UKB, we reevaluated the ApoE e4 allele association with COVID-19 test positivity, and with all-cause mortality following test-confirmed COVID-19. We restricted analyses to European-ancestry participants (3)(n= 451 367, 90% of sample) attending baseline assessment centers in England (n= 398 073) and excluded participants who died before the pandemic (set at February 1, 2020, n= 22 384). Singlenucleotide polymorphism data for rs429358 and rs7412 were used to determine ApoE genotypes. Our …