查看文章

Mobility impairment precedes Alzheimer’s disease (AD) and dementia. Potential mechanisms may involve mitochondrial dysfunction which is a hallmark of aging and links to both mobility impairment and brain health. In this study, we aimed to determine whether mitochondrial DNA copy number (mtDNA‐CN), a blood‐based marker related to mitochondrial function, would predict future dementia with and without the presence of early mobility impairment.

In the UK Biobank, we estimated mtDNA‐CN using fastMitoCalc from complete Whole Genome Sequencing data at study entry. Dementia diagnoses were ascertained from medical records, including AD and non‐AD dementia. Early mobility impairment was defined as having slow walking pace by self‐report at study entry. The absence of mobility impairment was defined as having steady average or brisk walking pace. In participants who …