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The paper describes the glossaLAB international project as a contribution to confront the urgent need of knowledge integration frameworks, as required to face global challenges that overwhelm disciplinary knowledge capacity. Under this scope, glossaLAB is devised to make contributions in three main aspects of such endeavor: (i) development of a sound theoretical framework for the unification of knowledge, (ii) establishment of broadly accepted methodologies and tools to facilitate the integration of knowledge, (iii) development of assessment criteria for the qualification of interdisciplinarity undertakings. The paper discusses the main components of the project and the solutions adopted to achieve the intended objectives at three different levels: at the technical level, glossaLAB aims at developing a platform for knowledge integration based on the elucidation of concepts, metaphors, theories and problems …