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This study is concerned with the development of a simple, rapid analytical method for simultaneously determining seven neonicotinoid insecticides (dinotefuran, nitenpyram, thiamethoxam, clothianidin, imidacloprid, acetamiprid and thiacloprid) in beeswax, by means of ultra-high performance liquid chromatography coupled to a quadrupole-time-of-flight mass detector. An efficient sample treatment is proposed (with average analyte recoveries between 93% and 106%) involving solvent extraction with a methanol and ethyl acetate mixture (70:30, v/v), centrifugation, freezing with dry ice, a dispersive solid phase extraction (enhanced matrix removal-lipid) followed by evaporation. Chromatographic analysis (10.5 min) was performed on a core-shell technology-based column (Kinetex® EVO C₁₈). The method was fully validated in terms of selectivity, ruggedness, limits of detection (LODs) and quantification (LOQs …