作者
Xiangfeng Lu, Zhongying Liu, Qingmei Cui, Fangchao Liu, Jianxin Li, Xiaoge Niu, Chong Shen, Dongsheng Hu, Keyong Huang, Jichun Chen, Xiaolong Xing, Yingxin Zhao, Fanghong Lu, Xiaoqing Liu, Jie Cao, Shufeng Chen, Hongxia Ma, Ling Yu, Xianping Wu, Xigui Wu, Ying Li, Huan Zhang, Xingbo Mo, Liancheng Zhao, Jianfeng Huang, Laiyuan Wang, Wanqing Wen, Xiao-Ou Shu, Fumihiko Takeuchi, Woon-Puay Koh, E Shyong Tai, Ching-Yu Cheng, Tien yin Wong, Xuling Chang, Mark Yan-Yee Chan, Wei Gao, Hong Zheng, Kexin Chen, Jing Chen, Jiang He, Clara Sze-man Tang, Karen Siu Ling Lam, Hung-fat Tse, Chloe Yu Yan Cheung, Atsushi Takahashi, Michiaki Kubo, Norihiro Kato, Chikashi Terao, Yoichiro Kamatani, Pak Chung Sham, Chew-Kiat Heng, Zhibin Hu, Y Eugene Chen, Tangchun Wu, Hongbing Shen, Cristen J Willer, Dongfeng Gu
发表日期
2022/5/7
期刊
European heart journal
卷号
43
期号
18
页码范围
1702-1711
出版商
Oxford University Press
简介
Aims
To construct a polygenic risk score (PRS) for coronary artery disease (CAD) and comprehensively evaluate its potential in clinical utility for primary prevention in Chinese populations.
Methods and results
Using meta-analytic approach and large genome-wide association results for CAD and CAD-related traits in East Asians, a PRS comprising 540 genetic variants was developed in a training set of 2800 patients with CAD and 2055 controls, and was further assessed for risk stratification for CAD integrating with the guideline-recommended clinical risk score in large prospective cohorts comprising 41 271 individuals. During a mean follow-up of 13.0 years, 1303 incident CAD cases were identified. Individuals with high PRS (the highest 20%) had about three-fold higher risk of CAD than the lowest 20% (hazard ratio 2.91, 95% confidence interval 2.43–3.49), with the lifetime …
学术搜索中的文章
X Lu, Z Liu, Q Cui, F Liu, J Li, X Niu, C Shen, D Hu… - European heart journal, 2022