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The canonical structure of DNA has four bases–Thymine (T), Adenine (A), Cytosine (C), and Guanine (G)–and DNA codes are regarded as words over the alphabet set Σ={A, C, G, T}, satisfying certain combinatorial conditions. Good DNA codes are desirable for DNA computation, DNA microarray technologies and molecular barcodes, etc. One of the main tasks in DNA code designing is to build more codewords and better GC-content for given fixed word length n. Existing heuristic methods work well for small n. In this paper, we present a systematic method for constructing good DNA codes for large n by using irreducible cyclic codes. Being different from traditional DNA constructions, our method is based on algebraic number theory rather than classical heuristic algorithms and the conventional coding theory. Furthermore, comparing with the traditional DNA codes, our codes have larger number of codewords and …