作者
Cesare Miglioli, Matteo Canini, Edoardo Vignotto, Nicolò Pecco, Mirko Pozzoni, Maria-Pia Victoria-Feser, Stéphane Guerrier, Massimo Candiani, Andrea Falini, Cristina Baldoli, Paolo I Cavoretto, Pasquale A Della Rosa
发表日期
2024/4/15
期刊
Heliyon
卷号
10
期号
7
出版商
Elsevier
简介
Background
Altered neurodevelopment is a major clinical sequela of Preterm Birth (PTB) being currently unexplored in-utero.
Aims
To study the link between fetal brain functional (FbF) connectivity and preterm birth, using resting-state functional magnetic resonance imaging (rs-fMRI).
Study design
Prospective single-centre cohort study.
Subjects
A sample of 31 singleton pregnancies at 28–34 weeks assigned to a low PTB risk (LR) (n = 19) or high PTB risk (HR) (n = 12) group based on a) the Maternal Frailty Inventory (MaFra) for PTB risk; b) a case-specific PTB risk gradient.
Methods
Fetal brain rs-fMRI was performed on 1.5T MRI scanner. First, directed causal relations representing fetal brain functional connectivity measurements were estimated using the Greedy Equivalence Search (GES) algorithm. HR vs. LR group differences were then tested with a novel ad-hoc developed Monte Carlo permutation test. Second, a …
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C Miglioli, M Canini, E Vignotto, N Pecco, M Pozzoni… - Heliyon, 2024