查看文章

Objectives

To determine the most cost-effective vaccination strategy for reducing future outbreaks of mpox among gay, bisexual, and other men who have sex with men (GBMSM) in the UK, following the 2022 outbreak.

Methods

A validated deterministic compartmental model of mpox transmission and vaccination was used to project costs and outcomes in terms of incremental cost per quality-adjusted life year (ICER) over a 10-year period, discounted at 3.5% and a£ 30,000/QALY willingness-to-pay threshold. The model was parameterized using data from the 2022 outbreak and a GBMSM survey undertaken in December 2021 (RiiSH-MPOX). Different vaccination strategies were compared to no vaccination. Vaccine protection was assumed to last 1 or 3 years and have effectiveness of 78% and 89% for 1 and 2 doses. Cost inputs for vaccination, outbreak response, and case management were obtained from UKHSA …