作者
Weiqiu Cheng, Oleksandr Frei, Dennis van der Meer, Yunpeng Wang, Kevin S O’Connell, Yunhan Chu, Shahram Bahrami, Alexey A Shadrin, Dag Alnæs, Guy FL Hindley, Aihua Lin, Naz Karadag, Chun-Chieh Fan, Lars T Westlye, Tobias Kaufmann, Espen Molden, Anders M Dale, Srdjan Djurovic, Olav B Smeland, Ole A Andreassen
发表日期
2021/9/1
期刊
JAMA psychiatry
卷号
78
期号
9
页码范围
1020-1030
出版商
American Medical Association
简介
Importance
Schizophrenia is a complex heritable disorder associated with many genetic variants, each with a small effect. While cortical differences between patients with schizophrenia and healthy controls are consistently reported, the underlying molecular mechanisms remain elusive.
Objective
To investigate the extent of shared genetic architecture between schizophrenia and brain cortical surface area (SA) and thickness (TH) and to identify shared genomic loci.
Design, Setting, and Participants
Independent genome-wide association study data on schizophrenia (Psychiatric Genomics Consortium and CLOZUK: n = 105 318) and SA and TH (UK Biobank: n = 33 735) were obtained. The extent of polygenic overlap was investigated using MiXeR. The specific shared genomic loci were identified by conditional/conjunctional false discovery rate analysis and were further examined in 3 independent cohorts. Data …
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W Cheng, O Frei, D van der Meer, Y Wang… - JAMA psychiatry, 2021