作者
Ruth G Tatevossian, Andrew RJ Lawson, Tim Forshew, Guy FL Hindley, David W Ellison, Denise Sheer
发表日期
2010/3
来源
Journal of cellular physiology
卷号
222
期号
3
页码范围
509-514
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Low‐grade astrocytomas (LGAs) are the most common type of brain tumor in children. Until recently, very little was known about the underlying biology and molecular genetics of these tumors. However, within the past year a number of studies have shown that the MAPK pathway is constitutively activated in a high proportion of LGAs. Several genetic aberrations which generate this deregulation of the MAPK pathway have been identified, most notably gene fusions between KIAA1549 and BRAF. In this review we summarize these findings, discuss how these gene fusions may arise and consider possible implications for diagnosis and treatment. J. Cell. Physiol. 222: 509–514, 2010. © 2009 Wiley‐Liss, Inc.
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RG Tatevossian, ARJ Lawson, T Forshew, GFL Hindley… - Journal of cellular physiology, 2010