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True drug allergies are relatively rare among children; however, children are often incorrectly labeled at the time of an acute viral infection. Urticaria or a delayed exanthem associated with an antibiotic is rarely followed-up in children with an appropriate diagnostic workup. Drug allergy labels are common and have significant associated cost and health implications. 1, 2 The prevalence of self-reported drug allergies among children ranges from 2.9% to 16.8%, whereas as few as 4% of these suspected drug allergies are confirmed after appropriate diagnostic work-up. 3 Antibiotics and NSAIDs account for the majority of reported drug allergies in children. 4 In the following sections, we will review current data related to the prevalence, diagnosis, and management of common pediatric drug allergies.