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Accurate biomarkers for predicting COVID‐19 severity have remained an unmet need due to an incomplete understanding of virus pathogenesis and heterogeneity among patients. Cellular senescence and its pro‐inflammatory phenotype are suggested to be a consequence of SARS‐CoV‐2 infection and potentially drive infection‐dependent pathological sequelae. Senescence‐associated markers in infected individuals have been identified primarily in the lower respiratory tract, while little is known about their presence in more easily accessible bio‐specimens. Here, we measured the abundance of senescence‐associated signatures in whole blood, plasma and peripheral blood mononuclear cells (PBMCs) of COVID‐19 patients and patients without an infection. Bulk transcriptomic and targeted proteomic assays revealed that the level of senescence‐associated markers, including the senescence‐associated …